When making a final decision of which purification platform will be chosen for the production of a new biopharmaceutical safety and low cost of purification are of primary importance.
To address these needs, and to meet the strict demands of the biopharmaceutical industry, BIA Separations has developed purification columns that are cGMP compliant and can be used in development stages or in full scale cGMP production.
CIM® cGMP Purification platform range:
• 8 mL CIM® cGMP Tube Monolithic Columns
• 80 mL CIM® cGMP Tube Monolithic Columns
• 800 mL CIM® cGMP Tube Monolithic Columns
• 8L CIM® cGMP Tube Monolithic Columns
CIM® cGMP purification platforms
CIM® Purification platforms integrate CIM® Monolithic Columns that combine the advantages of traditional particle resins (resolution) and membranes (capacity and flow rates) without the drawbacks (capacity, flow rates, packing, bubble traps, and high back pressures of particles and lack of resolution and high elution volumes for membranes) forming a very productive and efficient process. Since CIM monolith resin is made with a widely used polymer material that has a proven track record, CIM® Monoliths also meet safety requirements as well. CIM® cGMP Platforms can be used for viral and non-viral vaccines production, pDNA for gene therapy and vaccines, viral and non-viral vectors, large therapeutic protein and antibody purification.
Advantages:
• Fast and efficient production• Robustness of the platform
• Small footprint
• Easily scalable
• No air-bubble problems (no need for a bubble trap as air bubbles do not disturb the bed)
• No need for column packing
• Re-usable
• Easily sanitized
